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Treatment options against infections caused by rare but emerging moulds may be limited by their reduced susceptibility or resistance to clinically available antifungals. The investigational antifungal olorofim, which targets the… Click to show full abstract
Treatment options against infections caused by rare but emerging moulds may be limited by their reduced susceptibility or resistance to clinically available antifungals. The investigational antifungal olorofim, which targets the biosynthesis of pyrimidines within fungi, has activity against different species of filamentous fungi, including Aspergillus and Scedosporium/Lomentospora prolificans isolates that are resistant to available antifungals.
Keywords:
dehydrogenase inhibitor;
potent vitro;
activity;
olorofim potent;
dihydroorotate dehydrogenase;
inhibitor olorofim
Journal Title: Mycoses
Year Published: 2022
Link to full text (if available)
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Journal Title: Mycoses
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!