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Continuous dosing of nikkomycin Z against systemic candidiasis, in vivo and in vitro correlates

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Candidiasis is the most common cause of fungal sepsis, and new agents are of interest to ameliorate current deficiencies in therapy. Nikkomycin Z (NIKZ) is an inhibitor of chitin synthase,… Click to show full abstract

Candidiasis is the most common cause of fungal sepsis, and new agents are of interest to ameliorate current deficiencies in therapy. Nikkomycin Z (NIKZ) is an inhibitor of chitin synthase, interfering with fungal cell wall development.

Keywords: nikkomycin systemic; candidiasis vivo; candidiasis; systemic candidiasis; continuous dosing; dosing nikkomycin

Journal Title: Mycoses
Year Published: 2023

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