LAUSR

Meningioangiomatosis (MA) is a rare entity characterized by the perivascular spread of meningothelial and fibroblastic cells along the Virchow-Robin spaces of small leptomeningeal and intracortical blood vessels. In contrast to solitary MA, the perivascular cells in MA associated with meningioma often share the genetic alterations of the meningioma and thus represent an MA-like pattern of spread along perivascular Virchow-Robin spaces. Although a rare phenomenon, herein we demonstrate that a spectrum of non-meningothelial meningeal tumours (e.g. solitary fibrous tumour/hemangiopericytoma, atypical teratoid/rhabdoid tumour, and rhabdomyosarcoma) can similarly be associated with an MA-like pattern of perivascular spread. Analogously, the perivascular components of these tumours retain the signature immunoprofiles of their parent neoplasms, despite the otherwise benign appearing fibroblast-like cytology and marked perivascular hyalinization. Recognition of this morphologic mimicry can help prevent a diagnostic misinterpretation in these rare scenarios. This article is protected by copyright. All rights reserved.