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Baseline concentration of misfolded α‐synuclein aggregates in cerebrospinal fluid predicts risk of cognitive decline in Parkinson's disease

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The prognostic significance of misfolded α‐synuclein (α‐Syn) aggregates in Parkinson's disease (PD) has not been well investigated. The aim of this study was to reveal the relationship between misfolded α‐Syn… Click to show full abstract

The prognostic significance of misfolded α‐synuclein (α‐Syn) aggregates in Parkinson's disease (PD) has not been well investigated. The aim of this study was to reveal the relationship between misfolded α‐Syn aggregate concentration in cerebrospinal fluid (CSF) and cognitive decline risk in PD.

Keywords: misfolded synuclein; parkinson disease; concentration; cognitive decline; cerebrospinal fluid

Journal Title: Neuropathology and Applied Neurobiology
Year Published: 2019

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