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Spinal manifestations of CLN1 disease start during the early postnatal period

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To understand the progression of CLN1 disease and develop effective therapies we need to characterize early sites of pathology. Therefore, we performed a comprehensive evaluation of the nature and timing… Click to show full abstract

To understand the progression of CLN1 disease and develop effective therapies we need to characterize early sites of pathology. Therefore, we performed a comprehensive evaluation of the nature and timing of early CLN1 disease pathology in the spinal cord, which appears especially vulnerable, and how this may affect behaviour.

Keywords: manifestations cln1; disease start; pathology; cln1 disease; start early; spinal manifestations

Journal Title: Neuropathology and Applied Neurobiology
Year Published: 2020

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