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The molecular characteristics of low‐grade and high‐grade areas in desmoplastic infantile astrocytoma/ganglioglioma

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Desmoplastic infantile astrocytomas and gangliogliomas (DIA/DIGs) are rare brain tumours of infancy. A distinctive feature of their histopathology is a combination of low‐grade and high‐grade features. Most DIA/DIGs can be… Click to show full abstract

Desmoplastic infantile astrocytomas and gangliogliomas (DIA/DIGs) are rare brain tumours of infancy. A distinctive feature of their histopathology is a combination of low‐grade and high‐grade features. Most DIA/DIGs can be surgically resected and have a good prognosis. However, high‐grade features often dominate recurrent tumours, some of which have a poor outcome. In this study, we test the hypothesis that low‐grade and high‐grade areas in DIA/DIGs have distinct molecular characteristics.

Keywords: high grade; grade high; grade; desmoplastic infantile; grade areas; low grade

Journal Title: Neuropathology and Applied Neurobiology
Year Published: 2022

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