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Caspase‐6‐cleaved tau is relevant in Alzheimer's disease and marginal in four‐repeat tauopathies: Diagnostic and therapeutic implications

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Tau truncation (tr‐tau) by active caspase‐6 (aCasp‐6) generates tau fragments that may be toxic. Yet the relationship between aCasp‐6, different forms of tr‐tau and hyperphosphorylated tau (p‐tau) accumulation in human… Click to show full abstract

Tau truncation (tr‐tau) by active caspase‐6 (aCasp‐6) generates tau fragments that may be toxic. Yet the relationship between aCasp‐6, different forms of tr‐tau and hyperphosphorylated tau (p‐tau) accumulation in human brains with Alzheimer's disease (AD) and other tauopathies remains unclear.

Keywords: relevant alzheimer; disease marginal; cleaved tau; alzheimer disease; tau relevant; caspase cleaved

Journal Title: Neuropathology and Applied Neurobiology
Year Published: 2022

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