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Comprehensive analysis of intratumoural heterogeneity of somatic copy number alterations in diffuse glioma reveals clonality‐dependent prognostic patterns

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Intratumoural heterogeneity (ITH) has been implicated in tumour growth and progression as well as therapy resistance. However, the extent of ITH of somatic copy number alterations (ITH‐SCNAs) as a result… Click to show full abstract

Intratumoural heterogeneity (ITH) has been implicated in tumour growth and progression as well as therapy resistance. However, the extent of ITH of somatic copy number alterations (ITH‐SCNAs) as a result of tumour evolution and its influence on clinical outcomes in diffuse glioma (DG) remain poorly understood.

Keywords: intratumoural heterogeneity; number alterations; somatic copy; diffuse glioma; copy number

Journal Title: Neuropathology and Applied Neurobiology
Year Published: 2022

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