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Neuronal and astrocytic tetraploidy is increased in drug‐resistant epilepsy

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Epilepsy is one of the most prevalent neurological diseases. A third of patients with epilepsy remain drug‐resistant. The exact aetiology of drug‐resistant epilepsy (DRE) is still unknown. Neuronal tetraploidy has… Click to show full abstract

Epilepsy is one of the most prevalent neurological diseases. A third of patients with epilepsy remain drug‐resistant. The exact aetiology of drug‐resistant epilepsy (DRE) is still unknown. Neuronal tetraploidy has been associated with neuropathology. The aim of this study was to assess the presence of tetraploid neurons and astrocytes in DRE.

Keywords: tetraploidy; neuronal astrocytic; drug resistant; epilepsy; resistant epilepsy

Journal Title: Neuropathology and Applied Neurobiology
Year Published: 2022

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