Photo from wikipedia
Idiopathic inflammatory myopathies (IIM) are autoimmune inflammatory disorders leading to skeletal muscle weakness and disability. The pathophysiology of IIM is poorly understood due to the scarcity of animal disease models.… Click to show full abstract
Idiopathic inflammatory myopathies (IIM) are autoimmune inflammatory disorders leading to skeletal muscle weakness and disability. The pathophysiology of IIM is poorly understood due to the scarcity of animal disease models. Genetic deletion of Icos or Icosl (inducible T cell co‐stimulator/ligand) in non‐obese diabetic (NOD) mice leads to muscle disease. Our aim was to characterise Icos−/− NOD myopathy and to search for novel autoantibodies (aAbs) in this model.
Keywords:
non obese;
gene disruption;
disruption non;
icos gene;
mice;
obese diabetic
Journal Title: Neuropathology and Applied Neurobiology
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Neuropathology and Applied Neurobiology
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!