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DNA methylation‐based classification of glioneuronal tumours synergises with histology and radiology to refine accurate molecular stratification

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Glioneuronal tumours (GNTs) are poorly distinguished by their histology and lack robust diagnostic indicators. Previously, we showed that common GNTs comprise two molecularly distinct groups, correlating poorly with histology. To… Click to show full abstract

Glioneuronal tumours (GNTs) are poorly distinguished by their histology and lack robust diagnostic indicators. Previously, we showed that common GNTs comprise two molecularly distinct groups, correlating poorly with histology. To refine diagnosis, we constructed a methylation‐based model for GNT classification, subsequently evaluating standards for molecular stratification by methylation, histology and radiology.

Keywords: radiology; glioneuronal tumours; molecular stratification; methylation based; histology

Journal Title: Neuropathology and Applied Neurobiology
Year Published: 2023

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