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Upregulation of miR‐21 in renal ischaemic preconditioning (IPC) was associated with increased hypoxia inducible factor (HIF)‐1α expression. Hypoxic induction of HIF‐1α is mediated by inhibition of prolyl hydroxylase domain protein… Click to show full abstract
Upregulation of miR‐21 in renal ischaemic preconditioning (IPC) was associated with increased hypoxia inducible factor (HIF)‐1α expression. Hypoxic induction of HIF‐1α is mediated by inhibition of prolyl hydroxylase domain protein 2 (PHD2) .We hypothesized that miR‐21 regulated HIF‐1α by targeting PHD2 in the renal IPC.
Keywords:
prolyl hydroxylase;
hydroxylase domain;
domain protein;
ischaemic preconditioning
Journal Title: Nephrology
Year Published: 2017
Link to full text (if available)
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Journal Title: Nephrology
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!