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Deglycosylation influences the oxidation activity and antigenicity of myeloperoxidase

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Myeloperoxidase (MPO) is pathogenic in ANCA associated vasculitis. It also acts as bactericidal agent. MPO has five N‐linked glycosylation sites on its heavy chains. The effect of glycosylation pattern to… Click to show full abstract

Myeloperoxidase (MPO) is pathogenic in ANCA associated vasculitis. It also acts as bactericidal agent. MPO has five N‐linked glycosylation sites on its heavy chains. The effect of glycosylation pattern to the functions of MPO is barely known.

Keywords: antigenicity myeloperoxidase; myeloperoxidase; influences oxidation; oxidation activity; activity antigenicity; deglycosylation influences

Journal Title: Nephrology
Year Published: 2018

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