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Acetyl‐coenzyme A carboxylase beta gene polymorphism does not predict cardiovascular risk susceptibility in Chinese type 2 diabetic individuals

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Type 2 diabetes (T2D) is associated with significant cardiovascular (CV) morbidity and mortality. A single‐nucleotide polymorphism (SNP) in the acetyl‐coenzyme A carboxylase beta (ACACB) gene, rs2268388, reproducibly associates with diabetic… Click to show full abstract

Type 2 diabetes (T2D) is associated with significant cardiovascular (CV) morbidity and mortality. A single‐nucleotide polymorphism (SNP) in the acetyl‐coenzyme A carboxylase beta (ACACB) gene, rs2268388, reproducibly associates with diabetic nephropathy (DN). ACACB regulates fatty‐acid oxidation. As such, we assessed whether ACACB SNP rs2268388 was associated with CV disease in Chinese individuals with T2D.

Keywords: carboxylase beta; acetyl coenzyme; polymorphism; type; coenzyme carboxylase

Journal Title: Nephrology
Year Published: 2021

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