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Obesity is associated with hypothalamic–pituitary–testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor… Click to show full abstract
Obesity is associated with hypothalamic–pituitary–testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We also discuss therapeutic strategies targeting the AR for the treatment of obesity and their limitations and provide insight into the future research necessary to advance this field.
Keywords:
obesity;
androgen receptor;
role androgen
Journal Title: Obesity Reviews
Year Published: 2022
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Journal Title: Obesity Reviews
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!