LAUSR

Obesity, a burgeoning worldwide health system challenge, is associated with several comorbidities, including non‐alcoholic fatty liver disease (NAFLD), diabetes, atherosclerosis, and osteoarthritis, leading to serious problems to people's health. Adenosine is a critical extracellular signaling molecule that has essential functions in regulating most organ systems by binding to four G‐protein‐coupled adenosine receptors, denoted A1, A2A, A2B, and A3. Among the receptors, a growing body evidence highlights the key roles of the adenosine 2A receptor (A2AR) in obesity and related diseases. In the current review, we summarize the effects of A2AR in obesity and obesity‐associated non‐alcoholic fatty liver disease, diabetes, atherosclerosis, and osteoarthritis, to clarify the complicated impacts of A2AR on obesity and related diseases.