LAUSR

OBJECTIVE In this study, the effect of photodynamic therapy with topical corticosteroid in oral lichen planus patients was compared. MATERIALS AND METHOD In this randomized double blind clinical trial, 8 patients with bilateral oral OLP lesions were recruited. Toluidine blue was applied on the lesions of both sides; a 660nm diode laser InGaAlP was irradiated for 10 min (power: 25mW, fluence: 19.23 J/cm2 , probe cross-section: 0.78 cm2 ) for three sessions. In the control side of the oral mucosa, only sham laser was used. Follow up sessions were held on week 3 and 7. In week 3, oral paste triamcinolone acetonide 0.1% was prescribed. Response rates were assessed clinically by VAS, Thongprasom sign scoring, clinical severity index, efficacy indices, and the amount of reduction in the size of the lesions. Mann-Whitney test was used to evaluate the treatment outcomes. RESULTS In spite of control side, all scores improved significantly between session 0 and4 for the intervention side. The differences of changes in almost all scores between session 0 and 4 in both intervention and control sides were significantly considerable (p value<0.05). CONCLUSION Photodynamic therapy can be used as an alternative therapy alongside standard methods or as a new modality for refractory OLP. This article is protected by copyright. All rights reserved.