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HUCMSC‐derived Exosomes Suppress the Titanium Particles‐induced Osteolysis in Mice through Inhibiting CCL2 and CCL3

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Wear particles induce inflammation and the further osteolysis around the prosthesis, has been proven to be the main cause of aseptic hip joint loosening. In this research, we aimed to… Click to show full abstract

Wear particles induce inflammation and the further osteolysis around the prosthesis, has been proven to be the main cause of aseptic hip joint loosening. In this research, we aimed to clarify whether human umbilical cord mesenchymal stem cells (HUCMSCs) could inhibit the titanium particles‐induced osteolysis and shed light upon its mechanism.

Keywords: derived exosomes; osteolysis; induced osteolysis; titanium particles; particles induced; hucmsc derived

Journal Title: Orthopaedic Surgery
Year Published: 2023

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