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Conditional reprogramming of pediatric airway epithelial cells: A new human model to investigate early‐life respiratory disorders

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Airway epithelial cells (AEC) are quite difficult to access in newborns and infants. It is critically important to develop robust life‐extended models to conduct translational studies in this age group.… Click to show full abstract

Airway epithelial cells (AEC) are quite difficult to access in newborns and infants. It is critically important to develop robust life‐extended models to conduct translational studies in this age group. We propose the use of a recently described cell culture technology (conditionally reprogrammed cells—CRC) to generate continuous primary cell cultures from nasal and bronchial AEC of young children.

Keywords: conditional reprogramming; epithelial cells; reprogramming pediatric; airway epithelial; pediatric airway; life

Journal Title: Pediatric Allergy and Immunology
Year Published: 2017

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