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Effect of spirometry on exhaled nitric oxide values in asthmatic children

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Measurement of fractional exhaled nitric oxide (FeNO) is important for asthma management. Regarding interpretation of FeNO, the American Thoracic Society (ATS) / European Respiratory Society (ERS) guidelines recommended that FeNO… Click to show full abstract

Measurement of fractional exhaled nitric oxide (FeNO) is important for asthma management. Regarding interpretation of FeNO, the American Thoracic Society (ATS) / European Respiratory Society (ERS) guidelines recommended that FeNO should be done first because hyperventilation maneuvers like spirometry have been shown to transiently reduce the exhaled NO level (1,2,3,4). However, in daily clinical practice, there are some situations where we want to evaluate FeNO after hyperventilation. Because it is unclear how hyperventilation affects assessment of FeNO, this study was conducted to clarify the influence of hyperventilation (spirometry) on FeNO, and the reliability of the FeNO data obtained in such situation. This article is protected by copyright. All rights reserved.

Keywords: exhaled nitric; spirometry; effect spirometry; spirometry exhaled; nitric oxide; hyperventilation

Journal Title: Pediatric Allergy and Immunology
Year Published: 2019

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