LAUSR

Of the many immune components involved in asthma pathobiology, recent studies have focused on the potential roles of receptor for advanced glycation end products (RAGE).1 RAGE is a member of the immunoglobulin superfamily, which serves as a pattern-recognition receptor for many glycated and non-glycated ligands.1 Membrane-bound RAGE (mRAGE), through binding with ligands, activates various downstream inflammatory pathways.1 By contrast, the cleaved form-soluble RAGE (sRAGE)-functions as a decoy receptor through binding proinflammatory ligands destined for mRAGE, and hence offers anti-inflammatory effects.1 These RAGE pathways are involved in a range of lung diseases (e.g., acute respiratory distress syndrome) and are a candidate for targeted therapies.