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Perioperative anaphylaxis in children and first successful cisatracurium desensitization

Perioperative anaphylaxis (PA) is a rare life‐threatening complication of anesthesia, with few descriptions of its diagnosis and outcomes in the pediatric population. Many agents can be potential culprits, and drug… Click to show full abstract

Perioperative anaphylaxis (PA) is a rare life‐threatening complication of anesthesia, with few descriptions of its diagnosis and outcomes in the pediatric population. Many agents can be potential culprits, and drug provocation testing (DPT) to confirm the diagnosis is limited by the nature of anesthetic drugs. PA diagnosis and culprit identification remain a challenge. For patients with limited drug options, desensitization has not been reported. This study evaluated the results of skin and laboratory testing for pediatric patients with PA and provides the protocol and outcome of the first desensitization to cisatracurium, a neuromuscular blocking agent (NMBA).

Keywords: anaphylaxis children; perioperative anaphylaxis; children first; desensitization; cisatracurium

Journal Title: Pediatric Allergy and Immunology
Year Published: 2025

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