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Multidimensional cognitive impairment in unipolar and bipolar depression and the moderator effect of adverse childhood experiences

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Studies have demonstrated neuropsychological deficits across a variety of cognitive domains in depression. These deficits are observable both in major depressive disorder (MDD) and in bipolar disorder (BD) and are… Click to show full abstract

Studies have demonstrated neuropsychological deficits across a variety of cognitive domains in depression. These deficits are observable both in major depressive disorder (MDD) and in bipolar disorder (BD) and are present in each phase of the illness, including euthymia. Adverse childhood experiences (ACE) have been associated with an increased risk of developing psychiatric disorders and cognitive deficits. The aim of this study was to assess neuropsychological performances in a sample of MDD and BD patients during a depressive episode compared to healthy controls (HC) and, to investigate if ACE affect the cognitive profiles in the three groups.

Keywords: multidimensional cognitive; cognitive impairment; impairment unipolar; adverse childhood; childhood experiences

Journal Title: Psychiatry and Clinical Neurosciences
Year Published: 2017

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