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Hypofunction of N‐methyl‐D‐aspartate receptors (NMDAR) may contribute to the pathophysiology of schizophrenia (SCZ). Recently, the glycine cleavage system (GCS) was shown to affect NMDAR function in the brain. GCS functional… Click to show full abstract
Hypofunction of N‐methyl‐D‐aspartate receptors (NMDAR) may contribute to the pathophysiology of schizophrenia (SCZ). Recently, the glycine cleavage system (GCS) was shown to affect NMDAR function in the brain. GCS functional defects cause nonketotic hyperglycinemia, the atypical phenotype of which presents psychiatric symptoms similar to SCZ. Here, we examined the involvement of GCS in SCZ.
Keywords:
mutations glycine;
glycine cleavage;
cleavage system;
system genes
Journal Title: Psychiatry and Clinical Neurosciences
Year Published: 2018
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Journal Title: Psychiatry and Clinical Neurosciences
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!