LAUSR

Major depression is one of the most prevalent mental health problems in adolescents and is associated with increased risk for subsequent attempted or completed suicide, comprising more than half of the reported adolescent suicide victims at death. Nevertheless, adolescent depression is more frequently missed than that in adults, possibly due to the prominence of irritability, mood reactivity, and fluctuating symptoms. For the early detection of depression, screening scales are clinically important; therefore, the optimal cut-off score to detect major depressive disorder in various populations has been investigated. However, distributional patterns of item responses in the adolescent general population are limited. In order to detect adolescent depression, which is often overlooked, the distributional pattern of depression symptoms in the general population should be deeply understood. The Patient Health Questionnaire for Adolescents (PHQ-A) is a self-reporting questionnaire adapted from the adult version of the PHQ-9, one of the most used screening tools for major depression worldwide. The PHQ-A is used to screen for depression among adolescents in a developmentally appropriate fashion in accordance with the DSM-IV-TR criteria. As nine components of the PHQ-A match the ‘A’ diagnostic criteria for major depression in the DSM-5, the distributional pattern of PHQ-A item responses in the adolescent general population should be examined to deepen our understanding of various expressions of depression symptoms among adolescents. Therefore, this study provided distributional patterns of item responses and total scores using the PHQ-A among adolescents. Every year, a community-based school survey has been prospectively conducted to measure several mental health indicators and their associated factors among adolescents in Hirosaki (please see Appendix S1 for more information about Hirosaki City). Data were obtained in September 2019 targeting children between the 4th and 9th grades in public elementary and junior high schools. We distributed 8003 sets of the PHQ-A to the corresponding schools. Classroom teachers explained the contents of this survey and discussed the concept of informed consent with them. Additionally, we mailed letters and information on the study to each child’s primary caregiver(s), and we excluded the children whose primary caregivers indicated an intention of not wanting their children to participate; the cohort included a total of 7765 children (3850 boys [49.6%] and 3915 girls [50.4%]). Ethical approval was obtained from the Hirosaki University Committee on Medical Ethics (IRB#2019-1026). This study was conducted in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Before examining the distributional pattern of PHQ-A item responses, the psychometric properties of the PHQ-A for Japanese adolescents were confirmed, which have not been reported to date (please see Appendix S2). Table 1 displays the PHQ-A item responses. Item responses for all nine items showed a similar pattern. Such a distributional pattern was also reported in a PHQ-9 study in adults. The distribution of No. 9 (suicidal ideation) showed a difference between current and previous studies conducted on adult participants: 83.5% and 96.6% for not at all, 10.7% and 15.0% for several days, 3.1% and 0.6% for more than half the days, and 2.4% and 0.6% for nearly every day, respectively. This difference was statistically significant (χ = 530.1, d.f. = 3, P < 0.001), suggesting that adolescents may be more frequently prone to suicidal ideation and suicide attempts than adults. This result is considered to reflect the current situation in Japan where the suicide rate for adults is decreasing; however, those for children and adolescents remain high.