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Neural correlates of N‐back task performance and proposal for corresponding neuromodulation targets in psychiatric and neurodevelopmental disorders

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Working memory (WM) deficit represents the most common cognitive impairment in psychiatric and neurodevelopmental disorders, making the identification of its neural substrates a crucial step towards the conceptualization of restorative… Click to show full abstract

Working memory (WM) deficit represents the most common cognitive impairment in psychiatric and neurodevelopmental disorders, making the identification of its neural substrates a crucial step towards the conceptualization of restorative interventions. We present a meta‐analysis focusing on neural activations associated with the most commonly used task to measure WM, the N‐back task, in patients with schizophrenia, depressive disorder, bipolar disorder, and attention‐deficit/hyperactivity disorder. Showing qualitative similarities and differences in WM processing between patients and healthy controls, we propose possible targets for cognitive enhancement approaches.

Keywords: neural correlates; neurodevelopmental disorders; back task; task performance; psychiatric neurodevelopmental; correlates back

Journal Title: Psychiatry and Clinical Neurosciences
Year Published: 2022

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