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Circadian rest‐activity rhythm and longitudinal brain changes underlying late‐life cognitive decline

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The neurobiological substrates underlying the relationship of circadian rest‐activity rhythm (RAR) alteration with accelerated late‐life cognitive decline are not clearly understood. In the present study, the longitudinal relationship of objectively… Click to show full abstract

The neurobiological substrates underlying the relationship of circadian rest‐activity rhythm (RAR) alteration with accelerated late‐life cognitive decline are not clearly understood. In the present study, the longitudinal relationship of objectively measured circadian RAR with in vivo Alzheimer disease (AD) pathologies and cerebrovascular injury was investigated in older adults without dementia.

Keywords: life cognitive; circadian rest; late life; rest activity; activity rhythm; cognitive decline

Journal Title: Psychiatry and Clinical Neurosciences
Year Published: 2022

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