LAUSR

BACKGROUND Parental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are different by dementia subtypes and sex of parent and offspring. METHODS For this cross-sectional study, we harmonized and pooled data for 17,194 older adults from nine population-based cohorts of eight countries. These studies conducted face-to-face diagnostic interviews, physical and neurological examinations, and neuropsychological assessments to diagnose dementia. We investigated the associations of maternal and paternal history of dementia with the risk of dementia and its subtypes in offspring. RESULTS The mean age of the participants was 72.8 ± 7.9 years and 59.2% were female. Parental history of dementia was associated with higher risk of dementia (odds ratio [OR]=1.47, 95% confidence interval [CI]=1.15-1.86) and Alzheimer's disease (AD) (OR=1.72, 95% CI=1.31-2.26), but not with the risk of non-AD. This was largely driven by maternal history of dementia, which was associated with the risk of dementia (OR=1.51, 95% CI=1.15-1.97) and AD (OR=1.80, 95% CI=1.33-2.43) whereas paternal history of dementia was not. These results remained significant when males and females were analyzed separately (OR=2.14, 95% CI=1.28-3.55 in males; OR=1.68, 95% CI=1.16-2.44 for females). CONCLUSIONS Maternal history of dementia was associated with the risk of dementia and AD in both males and females. Maternal history of dementia may be a useful marker for identifying individuals at higher risk of AD and stratifying the risk for AD in clinical trials. This article is protected by copyright. All rights reserved.