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We described the development of multiple melanocytic nevi within long‐standing MF patches in four young patients. Mycosis fungoides (MF) patches are characterized by a regulatory‐like cytokine profile leading to local… Click to show full abstract
We described the development of multiple melanocytic nevi within long‐standing MF patches in four young patients. Mycosis fungoides (MF) patches are characterized by a regulatory‐like cytokine profile leading to local immune suppression. The proliferation of nevomelanocytes is regulated by cellular senescence mechanisms mediated by immune system. The immunosuppressive effect of MF infiltrate in conjunction with the systemic effect of treatments may play a specific role in the nevomelanogenesis of the patients herein described.
Journal Title: Pediatric Dermatology
Year Published: 2019
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