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Screening of carnitine and biotin deficiencies on tandem mass spectrometry

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It is important to assess pediatric patients for nutritional deficiency when they are receiving specific interventions, such as enteral feeding. We focused on measurement of C0 and 3‐hydroxyisovalerylcarnitine (C5‐OH) with… Click to show full abstract

It is important to assess pediatric patients for nutritional deficiency when they are receiving specific interventions, such as enteral feeding. We focused on measurement of C0 and 3‐hydroxyisovalerylcarnitine (C5‐OH) with tandem mass spectrometry (MS/MS), which is performed as part of the newborn mass screening. The purpose of this study was to investigate the usefulness of MS/MS for screening carnitine and biotin deficiencies.

Keywords: mass spectrometry; screening carnitine; mass; carnitine biotin; biotin deficiencies; tandem mass

Journal Title: Pediatrics International
Year Published: 2017

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