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Bronchopulmonary dysplasia (BPD) remains an important cause of morbidity and mortality in premature infants. There is currently no proven effective treatment modality for BPD, and inflammation and oxidative injury play… Click to show full abstract
Bronchopulmonary dysplasia (BPD) remains an important cause of morbidity and mortality in premature infants. There is currently no proven effective treatment modality for BPD, and inflammation and oxidative injury play an important role in the pathogenesis of this disease. This study investigated the histopathological and biochemical effects of bosentan, which is a non‐specific endothelin receptor antagonist with known antioxidant and anti‐inflammatory properties, on hyperoxia‐induced lung injury (HILI) in neonatal rats.
Journal Title: Pediatrics International
Year Published: 2019
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