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Utility of enzyme immunoassays for diagnosis of subacute sclerosing panencephalitis

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Subacute sclerosing panencephalitis (SSPE) is a progressive neurologic disorder caused by the measles virus (MV) and is identified by positive MV‐specific antibody titers, detected mainly by hemagglutination inhibition (HI) tests… Click to show full abstract

Subacute sclerosing panencephalitis (SSPE) is a progressive neurologic disorder caused by the measles virus (MV) and is identified by positive MV‐specific antibody titers, detected mainly by hemagglutination inhibition (HI) tests in the cerebrospinal fluid (CSF). However, an alternative method, the enzyme immunoassay (EIA), has increasingly become a preferred method for detecting MV antibodies. To establish the index for SSPE diagnosis using EIA, we investigated the correlation between HI and EIA titers of MV antibodies in SSPE patients.

Keywords: enzyme immunoassays; subacute sclerosing; sclerosing panencephalitis; utility enzyme

Journal Title: Pediatrics International
Year Published: 2020

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