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Increased tissue factor activity promotes thrombin generation at type 1 diabetes onset in children

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In type 1 diabetes (T1D), a prothrombotic status due to elevated coagulation factors coincides with metabolic derailment. In a previous study, we discovered altered thrombin generation profiles in children with… Click to show full abstract

In type 1 diabetes (T1D), a prothrombotic status due to elevated coagulation factors coincides with metabolic derailment. In a previous study, we discovered altered thrombin generation profiles in children with T1D. These alterations are potentially most pronounced at T1D onset and ameliorated after insulin treatment. We tested this hypothesis in a longitudinal study, measuring thrombin generation together with coagulation parameters in children at T1D onset and during follow‐up.

Keywords: tissue factor; generation; type diabetes; thrombin generation; increased tissue

Journal Title: Pediatric Diabetes
Year Published: 2020

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