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Comparison of toxicity following single versus tandem autologous transplant regimens for pediatric medulloblastoma

Medulloblastoma outcomes have improved with craniospinal irradiation and chemotherapy, but such therapy has resulted in poor neurocognitive outcomes for young patients. Chemotherapy‐only regimens with autologous transplant have been implemented with… Click to show full abstract

Medulloblastoma outcomes have improved with craniospinal irradiation and chemotherapy, but such therapy has resulted in poor neurocognitive outcomes for young patients. Chemotherapy‐only regimens with autologous transplant have been implemented with the intention of avoiding radiation. It is not yet known whether single or tandem transplantation is superior with respect to efficacy and/or safety.

Keywords: toxicity following; autologous transplant; medulloblastoma; tandem; comparison toxicity

Journal Title: Pediatric Transplantation
Year Published: 2022

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