LAUSR

Pediatric acute liver failure represents a significant health care concern with significant morbidity and mortality. High‐volume plasma exchange has been shown to serve as an effective blood purification technique that has allowed patients with ALF to survive to liver transplantation, or in some cases even spontaneous recovery. This study describes a novel anticoagulation protocol using a combination of citrate and heparin for high‐volume plasma exchange in pediatric acute liver failure patients and demonstrates the safety of high‐volume plasma exchange in pediatric acute liver failure patients.