Immunosuppression therapy following lung transplantation fails to prevent chronic rejection in many patients, which is associated with lack of suppression of cytotoxic mediators and pro‐inflammatory cytokines in peripheral blood T… Click to show full abstract
Immunosuppression therapy following lung transplantation fails to prevent chronic rejection in many patients, which is associated with lack of suppression of cytotoxic mediators and pro‐inflammatory cytokines in peripheral blood T and natural killer T (NKT)‐like cells. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) upregulate/downregulate pro‐inflammatory gene expression, respectively; however, differences in the activity of these enzymes following lung transplant are unknown. We hypothesized decreased HDAC2 expression and increased HAT expression in pro‐inflammatory lymphocytes following lung transplant.
Journal Title: Respirology
Year Published: 2017
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