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Peripheral airway dysfunction and relationship with symptoms in smokers with preserved spirometry

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Smokers develop respiratory symptoms and peripheral airway dysfunction even when spirometry is preserved. Multiple breath nitrogen washout (MBNW) and impulse oscillometry system (IOS) are potentially useful measures of peripheral airway… Click to show full abstract

Smokers develop respiratory symptoms and peripheral airway dysfunction even when spirometry is preserved. Multiple breath nitrogen washout (MBNW) and impulse oscillometry system (IOS) are potentially useful measures of peripheral airway function but they have not been compared in such subjects. We hypothesized that MBNW and IOS are jointly abnormal in smokers with normal spirometry and that these abnormalities relate to respiratory symptoms.

Keywords: airway dysfunction; relationship symptoms; dysfunction relationship; peripheral airway; symptoms smokers

Journal Title: Respirology
Year Published: 2018

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