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Effect of CPAP on airway reactivity and airway inflammation in children with moderate–severe asthma

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Asthma is characterized by airway hyperreactivity and airway inflammation. We previously demonstrated that adults with mild well‐controlled asthma exhibited a marked decrease in airway reactivity (PC20 increased >2‐fold) after using… Click to show full abstract

Asthma is characterized by airway hyperreactivity and airway inflammation. We previously demonstrated that adults with mild well‐controlled asthma exhibited a marked decrease in airway reactivity (PC20 increased >2‐fold) after using nocturnal continuous positive airway pressure (CPAP) for 1 week. If CPAP produces a similar suppression of airway reactivity in children with moderate–severe asthma, who require chronic use of corticosteroids, then this non‐pharmacological therapy might provide a beneficial alternative or supplemental therapy in these subjects.

Keywords: children moderate; airway inflammation; cpap; airway reactivity; airway; moderate severe

Journal Title: Respirology
Year Published: 2019

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