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Efficacy of corticosteroid and intravenous cyclophosphamide in acute exacerbation of idiopathic pulmonary fibrosis: A propensity score‐matched analysis

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Acute exacerbation (AE) is a leading cause of death in patients with idiopathic pulmonary fibrosis (IPF). Although optimal treatment for AE‐IPF remains unclear, high‐dose corticosteroids (CS) with/without immunosuppressants, including intravenous… Click to show full abstract

Acute exacerbation (AE) is a leading cause of death in patients with idiopathic pulmonary fibrosis (IPF). Although optimal treatment for AE‐IPF remains unclear, high‐dose corticosteroids (CS) with/without immunosuppressants, including intravenous cyclophosphamide (IVCY), are often used as empirical therapy. However, the survival benefit of adding IVCY to CS therapy is unknown. We investigated the efficacy of this therapy in patients with AE‐IPF.

Keywords: idiopathic pulmonary; intravenous cyclophosphamide; pulmonary fibrosis; acute exacerbation

Journal Title: Respirology
Year Published: 2019

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