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Anti‐protease levels in cystic fibrosis are associated with lung function, recovery from pulmonary exacerbations and may be gender‐related

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Neutrophil elastase (NE), is an important host defence against lung pathogens. Maintaining a homeostatic balance between proteases such as NE and anti‐proteases such as secretory leukocyte protease inhibitor (SLPI), is… Click to show full abstract

Neutrophil elastase (NE), is an important host defence against lung pathogens. Maintaining a homeostatic balance between proteases such as NE and anti‐proteases such as secretory leukocyte protease inhibitor (SLPI), is important to prevent tissue damage. In the cystic fibrosis (CF) lung, elevated protease levels and impaired anti‐protease defences contribute to tissue destruction.

Keywords: protease; lung; anti protease; protease levels; cystic fibrosis

Journal Title: Respirology
Year Published: 2023

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