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When Wnt binds to the N‐terminal of Frizzled, a conformational change occurs in the C‐terminal of Frizzled, which binds to Dishevelled1 (Dvl1), a Wnt signaling component protein. When Dvl1 binds… Click to show full abstract
When Wnt binds to the N‐terminal of Frizzled, a conformational change occurs in the C‐terminal of Frizzled, which binds to Dishevelled1 (Dvl1), a Wnt signaling component protein. When Dvl1 binds to the C‐terminal of Frizzled, the concentration of β‐catenin increases and it enters the nucleus to transmit cell proliferation signals. CXXC‐type zinc finger protein 5 (CXXC5) binds to the Frizzled binding site of Dvl1 and interferes with Dvl1–Frizzled binding. Therefore, blocking CXXC5–Dvl1 binding may induce Wnt signal transduction.
Journal Title: Skin Research and Technology
Year Published: 2023
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