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Recent “in vitro” studies describe nucleoside diphosphate–linked moiety X-type motif 15 (NUDT15) enzyme to be involved in the metabolismofganciclovir. 1,2 Wereportsevereleukopeniaduringther-apy with valganciclovir in a recent kidney transplant recipient with… Click to show full abstract
Recent “in vitro” studies describe nucleoside diphosphate–linked moiety X-type motif 15 (NUDT15) enzyme to be involved in the metabolismofganciclovir. 1,2 Wereportsevereleukopeniaduringther-apy with valganciclovir in a recent kidney transplant recipient with NUDT15 geneticvariation.Thiscasereportisthefirsttosubstantiatea theoretical postulate of increased valganciclovir toxicity with NUDT15 variation.
Keywords:
factor valganciclovir;
toxicity nudt15;
valganciclovir toxicity;
risk factor;
novel risk
Journal Title: Transplant Infectious Disease
Year Published: 2022
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Journal Title: Transplant Infectious Disease
Year Published: 2022
Link to full text (if available)
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recommendations!