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The continuing evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants with decreased susceptibility to neutralizing antibodies is of clinical importance. Several spike mutations associated with immune escape have… Click to show full abstract
The continuing evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants with decreased susceptibility to neutralizing antibodies is of clinical importance. Several spike mutations associated with immune escape have evolved independently in association with different variants of concern (VOCs). How and when these mutations arise is still unclear. We hypothesized that such mutations might arise in the context of persistent viral replication in immunosuppressed hosts.
Journal Title: Transplant Infectious Disease
Year Published: 2022
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