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High‐titer post‐vaccine COVID‐19 convalescent plasma for immunocompromised patients during the first omicron surge

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Transplant and hematologic malignancy patients have high Coronavirus disease 2019 (COVID‐19) mortality and impaired vaccination responses. Omicron variant evades several monoclonal antibodies previously used in immunocompromised patients. Polyclonal COVID‐19 convalescent… Click to show full abstract

Transplant and hematologic malignancy patients have high Coronavirus disease 2019 (COVID‐19) mortality and impaired vaccination responses. Omicron variant evades several monoclonal antibodies previously used in immunocompromised patients. Polyclonal COVID‐19 convalescent plasma (CCP) may provide broader neutralizing capacity against new variants at high titers. Vaccination increases severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) titer in convalescent donors.

Keywords: convalescent; covid convalescent; immunocompromised patients; convalescent plasma

Journal Title: Transplant Infectious Disease
Year Published: 2023

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