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Most cases of fetal and neonatal alloimmune thrombocytopenia (FNAIT) are caused by maternal alloantibodies against human platelet antigen‐1a (HPA‐1a). Alloimmunization mainly occurs in HPA‐1a–negative mothers who are carriers of the… Click to show full abstract
Most cases of fetal and neonatal alloimmune thrombocytopenia (FNAIT) are caused by maternal alloantibodies against human platelet antigen‐1a (HPA‐1a). Alloimmunization mainly occurs in HPA‐1a–negative mothers who are carriers of the HLA‐DRB3*01:01 allele. Recently, it has been reported that the combined presence of HLA‐DRB3*01:01 and HLA‐DRB4*01:01P was associated with severity of FNAIT. We tested this hypothesis by analyzing a large cohort of cases and controls.
Keywords:
fetal neonatal;
alloimmune thrombocytopenia;
hla;
neonatal alloimmune;
hla drb3;
human platelet
Journal Title: Transfusion
Year Published: 2017
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Journal Title: Transfusion
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!