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Spherocytic shift of red blood cells during storage provides a quantitative whole cell–based marker of the storage lesion

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Storage lesion may explain the rapid clearance of up to 25% of transfused red blood cells (RBCs) in recipients. Several alterations affect stored RBC but a quantitative, whole cell–based predictor… Click to show full abstract

Storage lesion may explain the rapid clearance of up to 25% of transfused red blood cells (RBCs) in recipients. Several alterations affect stored RBC but a quantitative, whole cell–based predictor of transfusion yield is lacking. Because RBCs with reduced surface area are retained by the spleen, we quantified changes in RBC dimensions during storage.

Keywords: quantitative whole; red blood; storage; whole cell; storage lesion; blood cells

Journal Title: Transfusion
Year Published: 2017

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