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Use of potassium adsorption filter for the removal of ammonia and potassium from red blood cell solution for neonates

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Ammonia in the plasma usually does not pass through the blood–brain barrier (BBB). However, it can affect the brain as a neurotoxin in neonates with anemia of prematurity. Excess intake… Click to show full abstract

Ammonia in the plasma usually does not pass through the blood–brain barrier (BBB). However, it can affect the brain as a neurotoxin in neonates with anemia of prematurity. Excess intake of ammonia should therefore be restricted in conditions involving BBB breakdown, such as in premature neonates. A potassium adsorption filter (PAF) can remove not only potassium, but also ammonia from red blood cell (RBC) solution. PAF for neonates (PAF‐n) has been recently introduced using small satellite packs. We evaluated the effects of PAF‐n on the removal of ammonia and potassium from RBC solution in small satellite packs.

Keywords: ammonia; adsorption filter; solution; blood; potassium adsorption

Journal Title: Transfusion
Year Published: 2018

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