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Cryopreservation of buffy coat–derived platelet concentrates photochemically treated with amotosalen and UVA light

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Cryopreserved platelets (CPPs) are considered a promising approach for extended platelet storage, bridging inventory shortages of conventionally stored platelets. It is unknown if platelet concentrates exposed to photochemical treatment (PCT)… Click to show full abstract

Cryopreserved platelets (CPPs) are considered a promising approach for extended platelet storage, bridging inventory shortages of conventionally stored platelets. It is unknown if platelet concentrates exposed to photochemical treatment (PCT) with amotosalen and ultraviolet A (UVA) light, to inactivate pathogens, are suitable for freezing. The objective of this study was to analyze potential effects of PCT on CPPs as compared with untreated CPPs.

Keywords: uva light; coat derived; platelet concentrates; cryopreservation buffy; buffy coat

Journal Title: Transfusion
Year Published: 2018

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