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A whole genome approach for discovering the genetic basis of blood group antigens: independent confirmation for P1 and Xga

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Although P1 and Xga are known to be associated with the A4GALT and XG genes, respectively, the genetic basis of antigen expression has been elusive. Recent reports link both P1… Click to show full abstract

Although P1 and Xga are known to be associated with the A4GALT and XG genes, respectively, the genetic basis of antigen expression has been elusive. Recent reports link both P1 and Xga expression with nucleotide changes in the promotor regions and with antigen‐negative phenotypes due to disruption of transcription factor binding.

Keywords: genome approach; whole genome; genetic basis; xga; approach discovering

Journal Title: Transfusion
Year Published: 2019

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