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Hypersensitivity transfusion reactions to platelet concentrate: a retrospective analysis of the French hemovigilance network

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Among labile blood products, platelet concentrates (PCs) are the leading cause of hypersensitivity transfusion reactions (HTRs). These reactions often lead to interruption of PC transfusion and can result in a… Click to show full abstract

Among labile blood products, platelet concentrates (PCs) are the leading cause of hypersensitivity transfusion reactions (HTRs). These reactions often lead to interruption of PC transfusion and can result in a prolonged transfusion process leading to significant morbidity and use of premedication and close monitoring for patients with a history of allergic transfusion reactions. The French hemovigilance database is one of the largest standardized databases providing information on HTRs following administration of labile blood products. In this study, we analyzed this database to assess the relative risk of HTR for each type of PC.

Keywords: transfusion; french hemovigilance; transfusion reactions; hypersensitivity transfusion

Journal Title: Transfusion
Year Published: 2019

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